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1

Finding New Hits in Neglected Disease Projects: Target or Phenotypic Based Screening?

H. Gilbert, Ian, Leroy, Didier, A. Frearson, Julie

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 149 KB

english, 2011

2

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Daniel Spinks, Dr. Leah S. Torrie, Dr. Stephen Thompson, Dr. Justin R. Harrison, Prof. Julie A. Frearson, Dr. Kevin D. Read, Prof. Alan H. Fairlamb, Prof. Paul G. Wyatt, Prof. Ian H. Gilbert

Journal:

Year:

2012

Language:

english

File:

PDF, 318 KB

english, 2012

3

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Deuan C. Jones, Irene Hallyburton, Laste Stojanovski, Kevin D. Read, Julie A. Frearson, Alan H. Fairlamb

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 412 KB

english, 2010

4

HTS and hit finding in academia – from chemical genomics to drug discovery

Julie A. Frearson, Iain T. Collie

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 726 KB

english, 2009

5

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

Daniel Spinks, Emma J. Shanks, Laura A. T. Cleghorn, Stuart McElroy, Deuan Jones, Daniel James, Alan H. Fairlamb, Julie A. Frearson, Paul G. Wyatt, Ian H. Gilbert

Journal:

Year:

2009

Language:

english

File:

PDF, 366 KB

english, 2009

6

The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis

Urich, Robert, Grimaldi, Raffaella, Luksch, Torsten, Frearson, Julie A., Brenk, Ruth, Wyatt, Paul G.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 5.47 MB

english, 2014

7

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Brand, Stephen, McElroy, Stuart P., Cleghorn, Laura A. T., Smid, Ondrej, Stojanovski, Laste, Price, Helen P., Guther, M. Lucia S., Torrie, Leah S., Robinson, David A., Frearson, Julie A.

Journal:

Year:

2010

Language:

english

File:

PDF, 907 KB

english, 2010

8

Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009)

John L. Richardson, Isabelle R. E. Nett, Deuan C. Jones, Mohamed H. Abdille, Ian H. Gilbert, Alan H. Fairlamb, Stephen Patterson, Deuan C. Jones, Emma J. Shanks, Julie A. Frearson, Paul G. Wyatt

Journal:

Year:

2009

Language:

english

File:

PDF, 1.00 MB

english, 2009

9

A tyrosine-phosphorylated 110–120-kDa protein associates with the C-terminal SH2 domain of phosphotyrosine phosphatase-1D in T cell receptor-stimulated T cells

Julie A. Frearson, Taolin Yi, Denis R. Alexander

Journal:

European Journal of Immunology

Year:

1996

Language:

english

File:

PDF, 561 KB

english, 1996

10

Design and Synthesis of Brain Penetrant Trypanocidal N -Myristoyltransferase Inhibitors

Bayliss, Tracy, Robinson, David A., Smith, Victoria C., Brand, Stephen, McElroy, Stuart P, Torrie, Leah S., Mpamhanga, Chido, Norval, Suzanne, Stojanovski, Laste, Brenk, Ruth, Frearson, Julie A, Read,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.42 MB

english, 2017

11

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

Daniel Spinks, Dr. Han B. Ong, Dr. Chidochangu P. Mpamhanga, Dr. Emma J. Shanks, Dr. David A. Robinson, Iain T. Collie, Dr. Kevin D. Read, Prof. Julie A. Frearson, Prof. Paul G. Wyatt, Dr. Ruth Brenk,

Journal:

Year:

2011

Language:

english

File:

PDF, 526 KB

english, 2011

12

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.74 MB

english, 2011

13

A Novel Allosteric Inhibitor of the Uridine Diphosphate N -Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei

Urbaniak, Michael D., Collie, Iain T., Fang, Wenxia, Aristotelous, Tonia, Eskilsson, Susanne, Raimi, Olawale G., Harrison, Justin, Navratilova, Iva Hopkins, Frearson, Julie A., van Aalten, Daan M. F.,

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.79 MB

english, 2013

14

Assessment of Pseudomonas aeruginosa N5,N10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target

Eadsforth, Thomas C., Gardiner, Mary, Maluf, Fernando V., McElroy, Stuart, James, Daniel, Frearson, Julie, Gray, David, Hunter, William N., Uversky, Vladimir N.

Journal:

Year:

2012

Language:

english

File:

PDF, 718 KB

english, 2012

15

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

Stephen Patterson, Deuan C. Jones, Emma J. Shanks, Julie A. Frearson, Ian H. Gilbert, Paul G. Wyatt, Alan H. Fairlamb

Journal:

Year:

2009

Language:

english

File:

PDF, 403 KB

english, 2009

16

Inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate metabolism in HL60 cells

CREBA, JUDITH A., FREARSON, JULIE, PRITCHARD, ANGELA

Journal:

Biochemical Society Transactions

Year:

1989

Language:

english

File:

PDF, 245 KB

english, 1989

17

Protein tyrosine phosphatases in T-cell development, apoptosis and signalling

Julie A. Frearson, Denis R. Alexander

Journal:

Immunology Today

Year:

1996

Language:

english

File:

PDF, 1.06 MB

english, 1996

18

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

Emma J. Shanks, Han B. Ong, David A. Robinson, Stephen Thompson, Natasha Sienkiewicz, Alan H. Fairlamb, Julie A. Frearson

Journal:

Analytical Biochemistry

Year:

2010

Language:

english

File:

PDF, 948 KB

english, 2010

19

Drug discovery in academia: the third way?

Frearson, Julie, Wyatt, Paul

Journal:

Expert Opinion on Drug Discovery

Year:

2010

Language:

english

File:

PDF, 685 KB

english, 2010

20

Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei

Ma, Jiangtao, Benz, Corinna, Grimaldi, Raffaella, Stockdale, Christopher, Wyatt, Paul, Frearson, Julie, Hammarton, Tansy C.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 3.96 MB

english, 2010

21

Back Cover: From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti- Trypanosoma brucei Drug Discovery Lead Molecules (ChemMedChem 7/2013)

Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A. T., Ojo, Kayode K., Van Voorhis, Wesley C., Brenk, Ruth, Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G.

Journal:

Year:

2013

File:

PDF, 876 KB

2013

22

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

Gardner, Nicola J., Gillespie, Peter J., Carrington, Jamie T., Shanks, Emma J., McElroy, Stuart P., Haagensen, Emma J., Frearson, Julie A., Woodland, Andrew, Blow, J. Julian

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 2.34 MB

english, 2017

23

Acetazolamide-based fungal chitinase inhibitors

Alexander W. Schüttelkopf, Ludovic Gros, David E. Blair, Julie A. Frearson, Daan M.F. van Aalten, Ian H. Gilbert

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.09 MB

english, 2010

24

Target assessment for antiparasitic drug discovery

Julie A. Frearson, Paul G. Wyatt, Ian H. Gilbert, Alan H. Fairlamb

Journal:

Trends in Parasitology

Year:

2007

Language:

english

File:

PDF, 979 KB

english, 2007

25

IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening

Tidten-Luksch, Naomi, Grimaldi, Raffaella, Torrie, Leah S., Frearson, Julie A., Hunter, William N., Brenk, Ruth, Campos-Olivas, Ramón

Journal:

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

26

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Mpamhanga, Chidochangu P., Spinks, Daniel, Tulloch, Lindsay B., Shanks, Emma J., Robinson, David A., Collie, Iain T., Fairlamb, Alan H., Wyatt, Paul G., Frearson, Julie A., Hunter, William N., Gilbert

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 3.68 MB

english, 2009

27

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

Urbaniak, Michael D., Mathieson, Toby, Bantscheff, Marcus, Eberhard, Dirk, Grimaldi, Raffaella, Miranda-Saavedra, Diego, Wyatt, Paul, Ferguson, Michael A. J., Frearson, Julie, Drewes, Gerard

Journal:

ACS Chemical Biology

Year:

2012

Language:

english

File:

PDF, 1.83 MB

english, 2012

28

Metabolism of inositol 1- and 4-monophosphates in HL60 promyelocytic leukaemia cells

Judith A. Creba, Frank Carey, Julie Frearson, Audrey McCulloch

Journal:

Cellular Signalling

Year:

1989

Language:

english

File:

PDF, 341 KB

english, 1989

29

Optimizing the use of CROs by academia and small companies

Lane, Rachel F., Friedman, Lauren G., Keith, Curtis, Braithwaite, Steven P., Frearson, Julie A., Lowe, David A., Longo, Frank M., Refolo, Lorenzo M., Watterson, D. Martin, Tsaioun, Katya, Shineman, Di

Journal:

Nature Reviews Drug Discovery

Year:

2013

Language:

english

File:

PDF, 103 KB

english, 2013

30

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti- Trypanosoma brucei Drug Discovery Lead Molecules

Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A. T., Ojo, Kayode K., Van Voorhis, Wesley C., Brenk, Ruth, Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.57 MB

english, 2013

31

Quinol derivatives as potential trypanocidal agents

Amy Capes, Stephen Patterson, Susan Wyllie, Irene Hallyburton, Iain T. Collie, Andrew J. McCarroll, Malcolm F.G. Stevens, Julie A. Frearson, Paul G. Wyatt, Alan H. Fairlamb, Ian H. Gilbert

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 482 KB

english, 2012

32

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

Ruth Brenk, Alessandro Schipani, Daniel James, Agata Krasowski, Ian Hugh Gilbert, Julie Frearson, Paul Graham Wyatt

Journal:

Year:

2008

Language:

english

File:

PDF, 603 KB

english, 2008

33

The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction

Julie A. Frearson, Denis R. Alexander

Journal:

Year:

1997

Language:

english

File:

PDF, 2.39 MB

english, 1997

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